Inhibition of the Sodium-Iodide Symporter By Perchlorate: An Evaluation of Lifestage Sensitivity Using Physiologically Based Pharmacokinetic (PBPK) Modeling (External Review Draft)
Notice - This site contains archived material(s)
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the NCEA Webmaster for assistance. Please use the contact us form if you need additional support.
This report provides an analysis of perchlorate-mediated inhibition of the sodium-iodide symporter (NIS) in humans using published PBPK models, focusing on the degree of NIS inhibition as a function of lifestage. The models provide information that may be used to address differences in human responses to perchlorate across lifestages.
|Oct 2008||EPA released an external review draft for public review and comment as a supporting document to the EPA Drinking Water Ruling.|
|Dec 2008||EPA released the consolidated comments from the independent external peer review.|
|Aug 2009||EPA released the summary of external peer review comments and disposition for the 2008 external review draft of the report with the draft report.|
|Aug 2009||EPA publishes the final report.|