INHIBITION OF THE SODIUM-IODIDE SYMPORTER BY PERCHLORATE: AN EVALUATION OF LIFESTAGE SENSITIVITY USING PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODELING (EXTERNAL REVIEW DRAFT)
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This report provides an analysis of perchlorate-mediated inhibition of the sodium-iodide symporter (NIS) in humans using published PBPK models, focusing on the degree of NIS inhibition as a function of lifestage. The models provide information that may be used to address differences in human responses to perchlorate across lifestages.
|Oct 2008||EPA released an external review draft for public review and comment as a supporting document to the EPA Drinking Water Ruling.|
|Dec 2008||EPA released the consolidated comments from the independent external peer review.|
|Aug 2009||EPA released the summary of external peer review comments and disposition for the 2008 external review draft of the report with the draft report.|
|Aug 2009||EPA publishes the final report.|