IRIS Toxicological Review of 1,4-Dioxane (External Review Draft, 2009)
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The draft Toxicological Review of 1,4-dioxane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to 1,4-dioxane. 1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coatings, adhesive agent, and an ingredient in chemical manufacture. Human health risk concerns for 1,4-dioxane are primarily related to exposure from drinking, ground, and surface waters, although these exposure concerns have not been well characterized.
This assessment contains the derivation of a chronic reference dose and cancer oral slope factor.
|Aug 1988||EPA released the assessment for 1,4-Dioxane.|
|Oct 2003||The IRIS reassessment of 1,4-dioxane was initiated.|
|May 2009||EPA released an external review draft for public review and comment.|
|Jun 2009||EPA announced a public listening session to be held July 6, 2009 and an external peer review workshop to be held on August 17, 2009 for the draft review report. A correction notice was posted on June 17, 2009 to confirm the listening session date as July 6, 2009.|
|Nov 2009||EPA releases the comments from the public comment period and external review workshop.|
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