Pathophysiological Progression Model for Selected Toxicological Endpoints

The existing continuum paradigms are effective models to organize toxicological data associated with endpoints used in human health assessments. A compendium of endpoints characterized along a pathophysiological continuum would serve to: weigh the relative importance of effects observed across chemicals, determination of species sensitivities and human relevance, serve as reference source for chemical-mode of action (MOA) characterization. The evaluation and organization of data that are both generic to the endpoint and chemical-specific may help in the characterization of the pathophysiological continuum of chemicals acting via similar pathways. Considering more than one framework (Schulte paradigm, and NRC model) will allow for the addition of events not considered in the traditional continuum framework (e.g. disruption of homeostatic controls)


PAGAN, I., L. T. HABER, AND D. G. Dodge. Pathophysiological Progression Model for Selected Toxicological Endpoints. Presented at Society for Toxicologic Pathology Annual Meeting, San Francisco, CA, June 22 - 26, 2008.