IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (External Review Draft)

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Abstract

EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of cis- and trans-1,2-dichloroethylene that will appear in the Integrated Risk Information System (IRIS) database.

The draft Toxicological Review of cis- and trans-1,2-dichloroethylene provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to cis- and trans-1,2-dichloroethylene. 1,2-Dichloroethylene is used as a solvent for waxes and resins, in rubber extraction, and as a coolant in refrigeration plants. The cis- and trans- isomers have slightly different physical, chemical, and biological properties. The trans-isomer is more widely used. 1,2-Dichloroethylene is frequently detected at federal and state hazardous waste sites across the country.

Impact/Purpose

The draft Toxicological Review of cis- and trans-1,2-dichloroethylene provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to cis- and trans-1,2-dichloroethylene.

Status

Following external peer review of the report, the final assessment will be posted to the IRIS database.

Citation

U.S. EPA. IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/006, 2009.

History/Chronology

Date Description
01-Sep 1988EPA posted the trans-1,2-dichloroethylene assessment (RfD only).
02-Dec 1990EPA posted the cis-1,2-dichloroethylene (qualitative cancer assessment only).
03-Aug 2009EPA hosted an interagency science discussion on the review of the draft IRIS Summary and Toxicological Review of cis-and trans-1,2-Dichloroethylene.
04-Sep 2009EPA released an external review draft of the assessment for public review and comment.
05-Nov 2009EPA announces the details of an external peer review workshop to be held on December 17, 2009 in a November 10, 2009 Federal Register Notice.
06-Jan 2010EPA releases the comments from the public comment period and external review workshop.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the key word EPA- HQ-ORD-2009-0348 (for the docket ID).

Federal Register Notices