US EPA

EPA conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessment of 1,2,3-trichloropropane (TCP) that once finalized will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization.

The draft Toxicological Review of 1,2,3-Trichloropropane provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to 1,2,3-trichloropropane. 1,2,3-Trichloropropane is an important industrial chemical used as a solvent for oils and fats, waxes, and resins, and has also been used in paint thinner and varnish remover and as a degreasing agent. 1,2,3-Trichloropropane is also generated as a by-product of the production of other chlorinated compounds such as epichlorohydrin, and is used as an intermediate in the production of some pesticides and polymers, such as polysulfide rubbers.

This assessment contains the derivation of a chronic reference dose and a chronic reference concentration, as well as a cancer characterization and the derivation of an oral slope factor.

This Tox Review provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to 1,2,3-trichloropropane.

Following the public review and comment period, the draft Toxicological Review will be reviewed by an external expert peer review meeting, to be announced in a proceeding Federal Register Notice.

U.S. EPA. IRIS Toxicological Review of 1,2,3-Trichloropropane (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, NCEA-S-1669.

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the key word EPA- HQ-ORD-2007-1083 (for the docket ID).