IRIS Toxicological Review of Chlordecone (Kepone) (External Review Draft)

Overview
History
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Abstract

EPA conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessment of chlordecone that will appear on the Integrated Risk Information System (IRIS) database.

The draft Toxicological Review of chlordecone provides scientific support and rationale for the hazard and dose-response assessment pertaining to subchronic and chronic exposure to chlordecone. Chlordecone is a chlorinated pesticide which before the cancelation of its production and use in the late 1970s was used primarily as an insecticide to control slugs, snails and fire ants. Chlordecone has been found at hazardous waste sites and is also a degradation product of the pesticide Mirex in the environment. Chlordecone was nominated for evaluation by the Superfund Technical Support Center.

This assessment contains the derivation of an oral reference dose for chronic exposure and a qualitative evaluation of suggestive carcinogenic potential.

Impact/Purpose

EPA is announcing a public comment period for the external review draft human health hazard and dose-response assessment of chlordecone that will appear on the Integrated Risk Information System (IRIS) database

Status

Following External Peer Review, the final assessment is scheduled to be posted to the IRIS database.

Citation

U.S. EPA. IRIS Toxicological Review of Chlordecone (Kepone) (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-07/004.

History/Chronology

Date	Description
01-2004	The chlordecone IRIS assessment was initiated in 2004. Chlordecone was nominated for assessment by the Superfund Technical Support Center. An assessment for chlordecone is not currently on IRIS.
02-Jan 2008	EPA releases an External Review Draft of the report.
03-Sep 2009	EPA released the Final toxicological review (PDF) (183 pp, 1.1M) and accompanying Summary for Chlordecone (Kepone) to the IRIS Database.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov website. From the site, select Environmental Protection Agency and the key word EPA- HQ-ORD-2007-1095 (for the docket ID).

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Toxicological Review of CHLORDECONE (KEPONE) (CAS No. 143-50-0) In Support of Summary Information on the Integrated Risk Information System (IRIS) (PDF) (133 pp, 1 MB, about PDF)
Charge for External Peer Review Panel Members (PDF) (3 pp, 18 KB, about PDF)
Consolidated Comments from the External Peer Review (Final) (PDF) (45 pp, 179 KB, about PDF)

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