IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane (2010 Final Report)

EPA is announcing the release of the final report, Toxicological Review of 1,1,2,2-Tetrachloroethane: in support of the Integrated Risk Information System (IRIS). The updated Summary for 1,1,2,2-Tetrachloroethane and accompanying Quickview have also been added to the IRIS Database.

The Toxicological Review of 1,1,2,2-tetrachloroethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to subchronic and chronic exposure to 1,1,2,2-tetrachloroethane. 1,1,2,2 Tetrachloroethane (1,1,2,2TCE; CASRN 79-34-5) is a synthetic halogenated hydrocarbon that is a colorless, nonflammable liquid at room temperature. The major use for 1,1,2,2 tetrachloroethane was in the production of trichloroethylene, tetrachloroethylene, and 1,2-dichloroethylene. This assessment contains the derivation of both a subchronic and chronic reference dose and an oral cancer slope factor. EPA is also putting forth for external review the statement that the human carcinogenic potential of 1,1,2,2-tetrachloroethane is “likely to be carcinogenic to humans”.


U.S. EPA. IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane (2010 Final Report). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/001, 2010.


September 2010EPA released the final tox report and summary document and posted these to the IRIS database.

This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.