IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane (Final Report)

EPA has finalized the Toxicological Review of 1,1,2,2-Tetrachloroethane: in support of the Integrated Risk Information System (IRIS). Now final, this assessment may be used by EPA’s program and regional offices to inform decisions to protect human health.

The Toxicological Review of 1,1,2,2-tetrachloroethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to subchronic and chronic exposure to 1,1,2,2-tetrachloroethane. 1,1,2,2 Tetrachloroethane (1,1,2,2TCE; CASRN 79-34-5) is a synthetic halogenated hydrocarbon that is a colorless, nonflammable liquid at room temperature. The major use for 1,1,2,2 tetrachloroethane was in the production of trichloroethylene, tetrachloroethylene, and 1,2-dichloroethylene. This assessment contains the derivation of both a subchronic and chronic reference dose and an oral cancer slope factor. EPA is also putting forth for external review the statement that the human carcinogenic potential of 1,1,2,2-tetrachloroethane is “likely to be carcinogenic to humans”.


U.S. EPA. IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane (Final Report). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/001F, 2010.


May 1987An assessment for 1,1,2,2-tetrachloroethane is currently available on IRIS and contains a carcinogenicity assessment last revised in 1994.
20031,1,2,2-tetrachloroethane was nominated for reassessment by the Office of Air and Radiation/OAQPS and Region 4.
Sep 2009EPA released an external review draft of the assessment for public review and comment.
Dec 2009EPA announced an external peer review workshop to be held on January 27, 2010 in a December 17, 2009 Federal Register Notice.
Feb 2010EPA released the comments from the external review workshop and the public comment period.
Aug 2010EPA hosted an interagency science discussion on the review of the draft document.
Sep 2010EPA posted the final Toxicological Review of 1,1,2,2-tetrachloroethane to the IRIS database.

This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.