Approaches for the Application of Physiologically Based Pharmacokinetic (PBPK) Models and Supporting Data in Risk Assessment (External Review Draft 2005)
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Topics covered include:
- the types of data required use of PBPK models in risk assessment,
- evaluation of PBPK models for use in risk assessment, and
- the application of these models to address uncertainties resulting from extrapolations (e.g. interspecies extrapolation) often used in risk assessment.
- a compilation of chemical partition coefficients and rate constants,
- algorithms for estimating chemical-specific parameters, and
- a list of publications relating to PBPK modeling.
Once this is done, the final report, which addresses both public and peer review comments, will be published and available from the EPA Web site.
|2003||EPA award released a solicitation for a contract to develop a report for the "Application of Physiologically Based Pharmacokinetic Data and Models in Risk Assessment."|
|2004||A draft document was released for internal review.|
|Jul 2005||EPA released the external review draft for public comment and peer review|
|Nov 2005||A draft of this report was subjected to an external review by a panel of independent experts.|
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.