IRIS Toxicological Review and Summary Documents for Chlordecone (Kepone) (2009 Final)

EPA is announcing the release of the final report, Toxicological Review of Chlorodecone (kepone): in support of the Integrated Risk Information System (IRIS). The updated Summary for Chlordecone (kepone) and accompanying Quickview have also been added to the IRIS Database.

Chlordecone was first produced in the United States in the early 1950s (IARC, 1979). It was introduced commercially in 1958 (Bus and Leber, 2001). Approximately 3.6 million pounds of chlordecone were produced in the United States between 1951 and 1975 (ATSDR, 1995). Chlordecone production in the United States ended in 1975 after intoxication from severe industrial exposure was observed in employees who worked at the only chlordecone manufacturing plant in the country (Bus and Leber, 2001). Typical signs of chlordecone intoxication include nervousness, headache, and tremor (Cannon et al., 1978). Chlordecone was primarily used as an insecticide (IARC, 1979). Specific applications have included control of the banana root borer, application on non-fruit-bearing citrus trees to control rust mites, control of wireworms in tobacco fields, control of apple scab and powdery mildew, control of the grass mole cricket, and control of slugs, snails, and fire ants (NLM, 2004a; ATSDR, 1995). Its registration was cancelled in 1978 (Metcalf, 2002; IARC, 1979).


U.S. EPA. IRIS Toxicological Review and Summary Documents for Chlordecone (Kepone) (2009 Final). U.S. Environmental Protection Agency, Washington, DC, 2009.

This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.