IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Discussion Draft) 2010
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The final Toxicological Review of 1,4-dioxane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to 1,4-dioxane. 1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coatings, adhesive agent, and an ingredient in chemical manufacture. Human health risk concerns for 1,4-dioxane are primarily related to exposure from drinking, ground, and surface waters, although these exposure concerns have not been well characterized. This assessment contains the derivation of a chronic reference dose and cancer oral slope factor.
|Aug 1988||EPA released the assessment for 1,4-Dioxane.|
|Oct 2003||The IRIS reassessment of 1,4-dioxane was started.|
|May 2009||EPA released an external review draft for public review and comment.|
|Sep 2009||EPA hosted an interagency science discussion on the review of the draft Toxicological Review of 1,4-dioxane.|
|Aug 2010||EPA releases the final assessment and the interagency review draft with comments.|