IRIS Toxicological Review and Summary Documents for Chloroethane (External Review Draft)
Notice - This site contains archived material(s)
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the NCEA Webmaster for assistance. Please use the contact us form if you need additional support.
Many females showed metastasis at a number of organ sites and died early due to tumor load. Uterine carcinogenesis is uncommon in rodents, but is more common in humans. The mode of action is suggested by positive genotoxicity and structural similarity to bromoethane which also causes uterine cancers in the B6C3F1 mouse. Metabolic studies show that either chloromethane (CM) or CE can deplete cellular GSH pools by excessive reductive conjugation. CM and CE, when in excess, can be oxidized to formaldehyde and acetaldehyde, respectively, and both intermediates are regarded as posing a hazard to humans. For hazard identification purposes CE is judged to be a likely human carcinogen. An estimate of cancer potency was also derived using a linearized multistage model, though uncertainty exists because of bioassay limitations.
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- (84 pp, 374 KB, about PDF)