External Peer Review of EPA’s MS-Combo Multi-Tumor Model and Test Report
In early 2011, the new MS_Combo model was externally reviewed by three experts in dose-response modeling and documented in a MS_Combo Peer Review Report (2011-03-03).
The peer reviewers were specifically asked to evaluate MS_Combo with respect to clarity of the documentation and model output, and the adequacy of testing methods and test results.
The reviewers generally agreed that the model produced statistically valid results but made several recommendations regarding enhancements that could facilitate or expand its practical application, and recommended how the documentation and outputs could be improved with respect to clarity.
EPA revised the MS_Combo software and documentation in response to these comments, incorporating most of the suggested revisions. Some suggested revisions that were considered important but not critical (e.g., reporting the entire estimation-error distribution for each estimated BMD) were postponed for implementation in a future version of MS_Combo. A technical background document for the MS_Combo program contains details necessary to understand the program's assumptions and application.
EPA revised the MS_Combo software and documentation in response to these comments, incorporating most of the suggested revisions. Some suggested revisions that were considered important but not critical (e.g., reporting the entire estimation-error distribution for each estimated BMD) were postponed for implementation in a future version of MS_Combo. A technical background document for the MS_Combo program contains details necessary to understand the program's assumptions and application.
Impact/Purpose
The primary purpose of this review was to ensure that the results of the draft EPA MS_Combo model calculates correct, accurate, and statistically valid estimates of the maximum likelihood and lower bound on a dose corresponding to fixed risk level, for a combination of two or more tumor types.
Citation
DAVIS, J. External Peer Review of EPA’s MS-Combo Multi-Tumor Model and Test Report. Cincinnati, OH.
History/Chronology
| Date | Description |
|---|---|
| Mar 2011 | Released external peer review of MS_Combo multitumor model |
This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.