Updated Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials, 2019)
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Abstract
This protocol includes strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.
The IRIS Program posts assessment protocols and protocol updates publicly on a chemical’s HERO project page, the IRIS website, and in systematic review repositories such as Zenodo (https://zenodo.org/record/2654896#.XMsScOhKjcs).
Impact/Purpose
Status
Citation
History/Chronology
Date | Description |
---|---|
Apr 2014 | EPA released preliminary meeting materials for chromium (VI), part 1, in preparation for the June 2014 Bimonthly Public Science Meeting. |
Jun 2014 | EPA hosted a public science meeting to discuss preliminary meeting materials for chromium (VI), part 1. |
Aug 2014 | EPA released preliminary meeting materials for chromium (VI), part 2, in preparation for the October 2014 Bimonthly Public Science Meeting. |
Oct 2014 | EPA hosted a public science meeting to discuss preliminary meeting materials for chromium (VI), part 2. |
Mar 2019 | EPA released the Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials). [Federal Register Notice Mar 15, 2019] |
Apr 2019 | EPA announced that they will host a public science meeting on April 24, 2019 (by webinar) to discuss the draft document. |
Oct 2022 | EPA released an update to the IRIS hexavlent chromium protocol. |
Aug 2024 | EPA released the final IRIS hexavalent chromium protocol. |
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials) (PDF) (41 pp, 2 MB, about PDF)
- An Update to the Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Oct 2022)
- Final Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (August 2024) (PDF) (159 pp, 2 MB, about PDF)
- IRIS Public Science Meeting (April 2019) -- Hexavalent Chromium