IRIS Toxicological Review of Dibutyl Phthalate (Dbp) (Preliminary Assessment Materials)
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Abstract
- Draft literature search strategies
- The approach for identifying studies
- The screening process for selecting pertinent studies
- The resulting list of pertinent studies
- Preliminary evidence tables
- The process for selecting studies to include in evidence tables
- The quality of the studies in the evidence tables
Dibutyl phthalate is used as a plasticizer for nitrocellulose, polyvinyl acetate, and polyvinyl chloride; a lubricant for aerosol valves; an antifoaming agent; a skin emollient; and a plasticizer in nail polish, fingernail elongators, and hair spray. Dibutyl phthalate is: 1) classified as a Hazardous Air Pollutant under the 1990 Clean Air Act amendments; 2) included on the Office of Prevention, Pesticides and Toxic Substances 1990 high production volume chemical list; 3) listed as a Toxic Release Inventory chemical; and 4) found at hazardous waste and Superfund sites. The assessment will present reference values for the noncancer effects of dibutyl phthalate (RfD and RfC), where supported by available data, and a cancer assessment. The Toxicological Review will be subject to an internal and external peer review.
Impact/Purpose
Citation
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Scoping Information, Preliminary Literature Search, Associated Strategy and Evidence Tables for DBP (PDF) (279 pp, 5 MB, about PDF)
- Primary literature search references sorted by author (DBP) (dynamic literature link - generated by HERO, leaving the IRIS website)
- Literature selection process for the DBP primary literature (dynamic literature link - generated by HERO, leaving the IRIS website)
- Mechanistic table (DBP) (dynamic literature link - generated by HERO, leaving the IRIS website)
- Targeted literature search for epidemiological references sorted by author (phthalate) (dynamic literature link - generated by HERO, leaving the IRIS website)
- Literature selection process for the DBP targeted epidemiological literature (dynamic literature link - generated by HERO, leaving the IRIS website)
- IRIS February 2015 Public Science Meeting & Presentations