US EPA

This is EPA's first assessment of the noncancer health effects and carcinogenic potential of tertiary amyl ethyl ether (TAEE). The IRIS program is preparing an assessment that will incorporate health effects information available for TAEE, and current risk assessment methods. The IRIS assessment for TAEE will consist of a Toxicological Review and IRIS Summary. The Toxicological Review is a critical review of the physiochemical and toxicokinetic properties of a chemical, and its toxicity in humans and experimental systems. The assessment will present reference values for the noncancer effects of TAEE (RfD and RfC), and a cancer assessment. The Toxicological Review and IRIS Summary will undergo Agency review which will be followed by Interagency review and external scientific peer review. The final product will reflect the Agency opinion on the overall toxicity of TAEE.

EPA is undertaking an Integrated Risk Information System (IRIS) health assessment for TAEE. IRIS is an EPA database containing Agency scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information in support of two steps of the risk assessment paradigm, i.e., hazard identification and dose-response evaluation. IRIS assessments are used in combination with specific situational exposure assessment information to evaluate potential public health risks associated with environmental contaminants.