SYSTEMS MODELING OF PROSTATE REGULATION AND RESPONSE TO ANTIANDROGEN
Abstract
The prostate is an androgen-dependent tissue that is an important site of disease in human males as well as an important indicator of androgen status in animals. The rat prostate is used for studying antiandrogenic drugs as well as for evaluation of endocrine disruption (e.g., Hershberger Assay). Pubertal changes in the prostate have been observed to be as sensitive to environmental antiandrogens as in utero effects. The goal of this research is to model the biology of prostate androgen function on a systems level to determine the factors responsible for the dose-response observable with androgens and antiandrogens in the male rat. This includes investigation of the roles of positive and negative feedback loops in prostatic response following castration and dosing with testosterone and/or antiandrogens.
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History/Chronology
| Date | Description |
|---|---|
| FY06 | Report on the prostate function model following castration. |
| FY07 | Report on dose-response with testosterone and/or antiandrogens. |
| FY08 | Evaluate linkage of the biologically-based model of prostate androgen-dependent gene regulation with genomics data. |