Provisional Peer-Reviewed Toxicity Values (PPRTVs)

Provisional Peer Reviewed Toxicity Values for Trans-Crotonaldehyde

Provisional Peer-Reviewed Toxicity Value (PPRTV) assessments support the U.S. EPA's mission to protect human health and the environment by identifying and characterizing the health hazards of chemicals of concern to the Superfund and RCRA Programs, and providing an important source of toxicity information and toxicity values for such chemicals. PPRTVs [provisional oral reference doses (p-RfDs), inhalation reference concentrations (p-RfCs), cancer risk values, and screening values] are derived after a review of the relevant scientific literature and using Agency methodologies, practices, and guidance for the development of toxicity values. Other EPA programs or external parties who choose of their own initiative to use PPRTV values are advised that Superfund resources will not be used to respond to challenges of these PPRTVs used in a context outside of the EPA Superfund Program.


The purpose of this document is to provide support for the hazard and dose response assessment pertaining to chronic and subchronic exposures to substances of concern, to present the major conclusions reached in the hazard identification and derivation of the PPRTVs, and to characterize the overall confidence in these conclusions and toxicity values.


U.S. EPA. Provisional Peer Reviewed Toxicity Values for Trans-Crotonaldehyde. U.S. Environmental Protection Agency, Washington, DC, EPA/690/R-21/001F, 2021.


Feb 2021EPA finalized and delivered the assessment to the Superfund Program. Subchronic and chronic RfDs were derived. The 2010 PPRTV assessment for Trans-Crotonaldehyde was archived.
Mar 2021EPA published the final report and values on the PPRTV website.

This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.

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Provisional Peer-Reviewed Toxicity Values (PPRTVs)