Provisional Peer-Reviewed Toxicity Values (PPRTVs)

Provisional Peer-Reviewed Toxicity Values for Perfluorobutane Sulfonic Acid (PFBS) and Related Compound Potassium Perfluorobutane Sulfonate

EPA announced the release of the final report Provisional Peer-Reviewed Toxicity Values for Perfluorobutane Sulfonic Acid (CASRN 375-73-5) and Related Compound Potassium Perfluorobutane Sulfonate (CASRN 29420-49-3). This report supports the EPA's mission to protect human health and the environment by identifying and characterizing the health hazards of chemicals of concern to the Superfund Program, and provide an important source of toxicity information and toxicity values. PPRTVs (provisional oral reference doses [p-RfDs], inhalation reference concentrations [p-RfCs], cancer risk values, and screening values) are derived after a review of the relevant scientific literature and use Agency methodologies, practices, and guidance for developing toxicity values. This assessment for perfluorobutane sulfonic acid (PFBS) updates and replaces the 2014 PPRTV assessment for PFBS.

Impact/Purpose

Provisional Peer-Reviewed Toxicity Values (PPRTV) assessments are developed for use by the Agency’s Office of Land and Emergency Management (OLEM) to support informed decisions in the Superfund program and at hazardous waste sites.

Citation

U.S. EPA. Provisional Peer-Reviewed Toxicity Values for Perfluorobutane Sulfonic Acid (PFBS) and Related Compound Potassium Perfluorobutane Sulfonate. U.S. Environmental Protection Agency, Washington, DC, EPA/690/R-21/001F, 2021.

History/Chronology

Jun 2018EPA conducted an independent external peer review of the draft report.
Nov 2018EPA released the draft document, Human Health Toxicity Values for Perfluorobutane Sulfonic Acid and Related Compound Potassium Perfluorobutane Sulfonate (Public Comment Draft) for a 60-day public comment period.
Oct 2020EPA conducted an independent external peer review of the draft report.
Apr 2021EPA released the final report and values on the PPRTV website. Subchronic and chronic RfDs were derived. The 2014 PPRTV assessment for PFBS was archived.

This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.

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Provisional Peer-Reviewed Toxicity Values (PPRTVs)