Provisional Peer-Reviewed Toxicity Values (PPRTVs)

Provisional Peer-Reviewed Toxicity Values for 2-Amino-4,6-Dinitrotoluene

EPA announced the release of the final report Provisional Peer-Reviewed Toxicity Values for 2-Amino-4,6-Dinitrotoluene (CASRN 35572-78-2). This report support the EPA's mission to protect human health and the environment by identifying and characterizing the health hazards of chemicals of concern to the Superfund Program, and provide an important source of toxicity information and toxicity values. PPRTVs (provisional oral reference doses [p-RfDs], inhalation reference concentrations [p-RfCs], cancer risk values, and screening values) are derived after a review of the relevant scientific literature and use Agency methodologies, practices, and guidance for developing toxicity values.


The purpose of this document is to provide support for the hazard and dose response assessment pertaining to chronic and subchronic exposures to substances of concern, to present the major conclusions reached in the hazard identification and derivation of the PPRTVs, and to characterize the overall confidence in these conclusions and toxicity values.


U.S. EPA. Provisional Peer-Reviewed Toxicity Values for 2-Amino-4,6-Dinitrotoluene. U.S. Environmental Protection Agency, Washington, DC, EPA/690/R-20/001F, 2020.


Jun 2020EPA finalized and delivered the assessment to the Superfund Program. Subchronic and chronic provisional RfDs, subchronic and chronic provisional RfCs, and a provisional oral slope factor were derived and this is the first entry of this chemical into the PPRTV collection.
Sep 2020EPA published the final report and values on the PPRTV website.

This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.

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Provisional Peer-Reviewed Toxicity Values (PPRTVs)