Provisional Peer-Reviewed Toxicity Values (PPRTVs)

Pentamethylphosphoramide (PMPA)

CASRN 10159-46-3

PPRTV Toxicity Values Summary Table

Noncancer Assessment

Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 10/15/2020
System RfD (mg/kg-day) Basis PoD UF Confidence
Respiratory 1 x 10-4 Increased incidence of nasal lesions NOAEL(HED) : 0.29 mg/kg-day 3000
Species Studied: Rats/M
Principal Study: Keller et al. (1997) as cited in U.S. EPA (2012d)


Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 10/15/2020
System RfD (mg/kg-day) Basis PoD UF Confidence
Respiratory 1 x 10-3 Increased incidence of nasal lesions NOAEL(HED) : 0.29 mg/kg-day 300
Species Studied: Rats/M
Principal Study: Keller et al. (1997) as cited in U.S. EPA (2012d)


Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 10/15/2020
Not determined

Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 10/15/2020
Not determined

Cancer Assessment

Weight of Evidence for CancerLast Updated: 10/15/2020
IN - Inadequate information to assess carcinogenic potential

Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 10/15/2020
Not determined

Estimate of Carcinogenic Risk from Inhalation ExposureLast Updated: 10/15/2020
Not determined

Provisional Peer-Reviewed Toxicity Values (PPRTVs)