Provisional Peer-Reviewed Toxicity Values (PPRTVs)

2-Ethylhexanol

CASRN 104-76-7

PPRTV Toxicity Values Summary Table

Noncancer Assessment

Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 04/23/2019
System RfD (mg/kg-day) Basis PoD UF Confidence
Developmental 7 x 10-2 Increased fetal skeletal variations BMDL : 7.37 mg/kg-day 100
Species Studied: Rat/M and F
Principal Study: Hellwig and Jackh (1997); Confidential (1991)


Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 04/23/2019
System RfD (mg/kg-day) Basis PoD UF Confidence
Developmental 7 x 10-2 Increased fetal skeletal variations BMDL : 7.37 mg/kg-day 100
Species Studied: Rat/M and F
Principal Study: Hellwig and Jackh (1997); Confidential (1991)


Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 04/23/2019
System RfC (mg/m3) Basis PoD UF Confidence
Respiratory 4 x 10-4 Increased diameter of Bowman's glands in the olfactory epithelium of the nasal cavity BMCL : 1.11 mg/m3 3000
Species Studied: Mouse/M
Principal Study: Miyake et al. (2016)


Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 04/23/2019
System RfC (mg/m3) Basis PoD UF Confidence
Respiratory 4 x 10-3 Increased diameter of Bowman's glands in the olfactory epithelium of the nasal cavity BMCL : 1.11 mg/m3 300
Species Studied: Mouse/M
Principal Study: Miyake et al. (2016)

Cancer Assessment

Weight of Evidence for CancerLast Updated: 04/23/2019
SU - Suggestive Evidence of Carcinogenic Potential

Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 04/23/2019
Oral Slope Factor: 9.5 x 10-3 per mg/kg-day
Tumor site(s): Hepatic
Cancer: Hepatocellular (carcinoma or adenoma)
Species Studied: Mouse/M
Duration:
Principal Study: Astill et al. (1996b); BASF (1991b)
Note:

Estimate of Carcinogenic Risk from Inhalation ExposureLast Updated: 04/23/2019
Not determined

Provisional Peer-Reviewed Toxicity Values (PPRTVs)