Total Petroleum Hydrocarbons (Aromatic High)
CASRN VARIOUS
PPRTV Toxicity Values Summary Table
Noncancer Assessment
Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 10/31/2022
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 10/31/2022
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Developmental | 3 x 10-4 | Neurodevelopment (Neurobehavioral changes) | BMDL1SD : 0.092 mg/kg-day | 300 | Medium |
Species Studied: Rat M/F
Duration: PNDs 5-11
Principal Study: Chen et al. (2012) as cited in U.S. EPA (2017a)
Note: Screening value based on data for benzo[a]pyrene
Duration: PNDs 5-11
Principal Study: Chen et al. (2012) as cited in U.S. EPA (2017a)
Note: Screening value based on data for benzo[a]pyrene
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 10/31/2022
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Developmental | 3 x 10-4 | Neurodevelopment (Neurobehavioral changes) | BMDL1SD : 0.092 mg/kg-day | 300 | Medium |
Species Studied: Rat M/F
Duration: PNDs 5-11
Principal Study: Chen et al. (2012) as cited in U.S. EPA (2017a)
Note: Screening value based on data for benzo[a]pyrene
Duration: PNDs 5-11
Principal Study: Chen et al. (2012) as cited in U.S. EPA (2017a)
Note: Screening value based on data for benzo[a]pyrene
Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 10/31/2022
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 10/31/2022
| System | RfC (mg/m3) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Developmental | 2 x 10-6 | Decreased embryo/fetal survival | LOAEL(HEC) : 0.0046 mg/m3 | 3000 | Low/Medium |
Species Studied: Rat M/F
Duration: 4h/d on GDs 11-20
Principal Study: Archibong et al. (2002) as cited in U.S. EPA (2017a)
Note: Screening value based on data for benzo[a]pyrene
Duration: 4h/d on GDs 11-20
Principal Study: Archibong et al. (2002) as cited in U.S. EPA (2017a)
Note: Screening value based on data for benzo[a]pyrene
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 10/31/2022
| System | RfC (mg/m3) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Developmental | 2 x 10-6 | Decreased embryo/fetal survival | LOAEL(HEC) : 0.0046 mg/m3 | 3000 | Low/Medium |
Species Studied: Rat M/F
Duration: 4h/d on GDs 11-20
Principal Study: Archibong et al. (2002) as cited in U.S. EPA (2017a)
Note: Screening value based on data for benzo[a]pyrene
Duration: 4h/d on GDs 11-20
Principal Study: Archibong et al. (2002) as cited in U.S. EPA (2017a)
Note: Screening value based on data for benzo[a]pyrene
Cancer Assessment
Weight of Evidence for CancerLast Updated: 10/30/2022
IN - Inadequate Information to Assess Carcinogenic Potential
Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 10/31/2022
Not determined
Estimate of Carcinogenic Risk from Inhalation ExposureLast Updated: 10/31/2022
Unit Risk Factor: 2 x 10-4 per mg/kg-day
Tumor site(s):
Cancer: Pituitary adenomas or adenocarcinomas
Species Studied: Mouse/F
Duration:
Principal Study: Daughtrey et al. (1989) and Biodynamics (1993) both cited in U.S. EPA(2009b)
Note: Screening value based on data for commercial hexane. Please refer to Provisional Peer Reviewed Toxicity Values for the Aromatic High Carbon Range Total Petroleum Hydrocarbon (TPH) Fraction (Cancer) (External Review Draft) for information on cancer oral and inhalation values.
IN - Inadequate Information to Assess Carcinogenic Potential
Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 10/31/2022
Not determined
Estimate of Carcinogenic Risk from Inhalation ExposureLast Updated: 10/31/2022
Unit Risk Factor: 2 x 10-4 per mg/kg-day
Tumor site(s):
Cancer: Pituitary adenomas or adenocarcinomas
Species Studied: Mouse/F
Duration:
Principal Study: Daughtrey et al. (1989) and Biodynamics (1993) both cited in U.S. EPA(2009b)
Note: Screening value based on data for commercial hexane. Please refer to Provisional Peer Reviewed Toxicity Values for the Aromatic High Carbon Range Total Petroleum Hydrocarbon (TPH) Fraction (Cancer) (External Review Draft) for information on cancer oral and inhalation values.