Styrene-Acrylonitrile (SAN) Trimer
CASRN VARIOUS
PPRTV Toxicity Values Summary Table
Noncancer Assessment
Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 08/11/2014
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 08/11/2014
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Hepatic , Nervous |
3 x 10-3 | Increased incidence of chronic active inflammation in males Increased incidence of sciatic nerve degeneration in females |
BMDL10 : 0.77 mg/kg-day | 300 | Medium |
Species Studied: Rat
Duration: 2 years, postweaning
Principal Study: NTP 2012
Note: The BMDL10 of 3.2 was converted to a HEC of 0.77 mg/kg-day.
Duration: 2 years, postweaning
Principal Study: NTP 2012
Note: The BMDL10 of 3.2 was converted to a HEC of 0.77 mg/kg-day.
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 08/11/2014
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Hepatic | 8 x 10-3 | Increased absolute liver weight | BMDL10 : 2.4 mg/kg-day | 300 | Medium |
Species Studied: Rat
Duration: 13 weeks, postweaning
Principal Study: NTP 2012
Note: The BMDL10 of 10 was converted to a HEC of 2.4 mg/kg-day.
Duration: 13 weeks, postweaning
Principal Study: NTP 2012
Note: The BMDL10 of 10 was converted to a HEC of 2.4 mg/kg-day.
Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 08/11/2014
Data are inadequate to derive a chronic RfC.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 08/11/2014
Data are inadequate to derive a subchronic RfC.
Data are inadequate to derive a chronic RfC.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 08/11/2014
Data are inadequate to derive a subchronic RfC.
Cancer Assessment
Weight of Evidence for CancerLast Updated: 08/11/2014
IN - Inadequate information to assess carcinogenic potential
IN - Inadequate information to assess carcinogenic potential