Tris(2-chloroethyl)phosphate
CASRN 115-96-8
PPRTV Toxicity Values Summary Table
Noncancer Assessment
Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/30/2009
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/30/2009
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Hepatic , Urinary |
7 x 10-3 | Increased absolute and relative weight Increased absolute and relative weight |
BMDL : 6.9 mg/kg-day | 1000 | Medium |
Species Studied: Rat
Duration: 5 d/wk, 16 weeks
Principal Study: NTP 1991
Note: The BMDL of 9.66 mg/kg-day was adjusted for continuous exposure.
Duration: 5 d/wk, 16 weeks
Principal Study: NTP 1991
Note: The BMDL of 9.66 mg/kg-day was adjusted for continuous exposure.
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/30/2009
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Hepatic , Urinary |
2 x 10-2 | Increased absolute and relative weight Increased absolute and relative weight |
BMDL : 6.9 mg/kg-day | 300 | Medium |
Species Studied: Rat
Duration: 5 d/wk, 16 weeks
Principal Study: NTP 1991
Note: The BMDL of 9.66 mg/kg-day was adjusted for continuous exposure.
Duration: 5 d/wk, 16 weeks
Principal Study: NTP 1991
Note: The BMDL of 9.66 mg/kg-day was adjusted for continuous exposure.
Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 09/30/2009
Data are inadequate to derive a chronic RfC.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 09/30/2009
Data are inadequate to derive a subchronic RfC.
Data are inadequate to derive a chronic RfC.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 09/30/2009
Data are inadequate to derive a subchronic RfC.
Cancer Assessment
Weight of Evidence for CancerLast Updated: 09/30/2009
LI - Likely to be carcinogenic to humans
Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 09/30/2009
Oral Slope Factor: 2 x 10-2 per mg/kg-day
Tumor site(s):
Cancer: Tubular cell adenomas and carcinomas
Species Studied: Rat
Duration: 104 weeks
Principal Study: NTP 1991, Matthews et al. 1993
Note: The BMDL was adjusted for continuous exposure and converted to a human equivalent dose.
LI - Likely to be carcinogenic to humans
Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 09/30/2009
Oral Slope Factor: 2 x 10-2 per mg/kg-day
Tumor site(s):
Cancer: Tubular cell adenomas and carcinomas
Species Studied: Rat
Duration: 104 weeks
Principal Study: NTP 1991, Matthews et al. 1993
Note: The BMDL was adjusted for continuous exposure and converted to a human equivalent dose.