Tributyl Phosphate
CASRN 126-73-8
PPRTV Toxicity Values Summary Table
Noncancer Assessment
Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 11/08/2010
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 11/08/2010
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Other | 1 x 10-2 | Occasional salivation | LOAEL : 32.5 mg/kg-day | 3000 | Medium |
Species Studied: Rat
Duration: 7 day/wk, 13 weeks
Principal Study: Healy et al. 1995 (Bio-Research Laboratories 1991)
Note: The subchronic LOAEL is used as the POD for calculation because it is lower than other potential PODs.
Duration: 7 day/wk, 13 weeks
Principal Study: Healy et al. 1995 (Bio-Research Laboratories 1991)
Note: The subchronic LOAEL is used as the POD for calculation because it is lower than other potential PODs.
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 11/08/2010
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Other | 3 x 10-2 | Occasional salivation | LOAEL : 32.5 mg/kg-day | 1000 | Medium/High |
Species Studied: Rat
Duration: 7 day/wk, 13 weeks
Principal Study: Healy et al. 1995 (Bio-Research Laboratories 1991)
Note: Lethality from aspiration of saliva is an early cholinergic sign of organophosphate toxicity
Duration: 7 day/wk, 13 weeks
Principal Study: Healy et al. 1995 (Bio-Research Laboratories 1991)
Note: Lethality from aspiration of saliva is an early cholinergic sign of organophosphate toxicity
Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 11/08/2010
Data are inadequate to derive a chronic RfC.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 11/08/2010
Data are inadequate to derive a subchronic RfC.
Data are inadequate to derive a chronic RfC.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 11/08/2010
Data are inadequate to derive a subchronic RfC.
Cancer Assessment
Weight of Evidence for CancerLast Updated: 11/08/2010
LI - Likely to be carcinogenic to humans
Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 11/08/2010
Oral Slope Factor: 9 x 10-3 per mg/kg-day
Tumor site(s):
Cancer: Transitional cell and squamous cell carcinomas and papillomas
Species Studied: Rat
Duration: 2 years
Principal Study: Auletta et al. 1998a
Note: Linear low-dose extrapolation was conducted.
Estimate of Carcinogenic Risk from Inhalation ExposureLast Updated: 11/08/2010
Data are inadequate to derive an inhalation unit risk.
LI - Likely to be carcinogenic to humans
Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 11/08/2010
Oral Slope Factor: 9 x 10-3 per mg/kg-day
Tumor site(s):
Cancer: Transitional cell and squamous cell carcinomas and papillomas
Species Studied: Rat
Duration: 2 years
Principal Study: Auletta et al. 1998a
Note: Linear low-dose extrapolation was conducted.
Estimate of Carcinogenic Risk from Inhalation ExposureLast Updated: 11/08/2010
Data are inadequate to derive an inhalation unit risk.