Provisional Peer-Reviewed Toxicity Values (PPRTVs)

2,4,6-Tribromophenol

CASRN 118-79-6

PPRTV Toxicity Values Summary Table

Noncancer Assessment

Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/03/2009
See attachment to the assessment's appendix for quantitative screening values.


Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/03/2009
System RfD (mg/kg-day) Basis PoD UF Confidence
Urinary 9 x 10-2 Increased serum creatinine BMDL : 92 mg/kg-day 1000 Low
Species Studied: Rat
Duration: 14 days prior to mating through day 3 of lactation
Principal Study: Tanaka et al. 1999
Note: Benmark dose modeling was used to calculate a BMDL(1SD). The LOAEL is 300 mg/kg-day.



Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 09/03/2009
Data are inadequate to derive a chronic RfC.


Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 09/03/2009
Data are inadequate to derive a subchronic RfC.


Cancer Assessment

Weight of Evidence for CancerLast Updated: 09/03/2009
IN - Inadequate information to assess carcinogenic potential.

Provisional Peer-Reviewed Toxicity Values (PPRTVs)