Provisional Peer-Reviewed Toxicity Values (PPRTVs)

3,4-Toluenediamine

CASRN 496-72-0

PPRTV Toxicity Values Summary Table

Noncancer Assessment

Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 08/13/2021
System RfD (mg/kg-day) Basis PoD UF Confidence
Hepatic 1 x 10-4 Increased serum AST NOAEL(HED) : 0.32 mg/kg-day 3000
Species Studied: Rat/Female
Principal Study: Hill (1997) as cited in SCCP (2007) and reported in U.S. EPA (2013)
Note: See attachment to the assessment's appendix for quantitative screening values.


Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 08/13/2021
System RfD (mg/kg-day) Basis PoD UF Confidence
Hepatic 1 x 10-3 Increased serum AST NOAEL(HED) : 0.32 mg/kg-day 300
Species Studied: Rat/Female
Principal Study: Hill (1997) as cited in SCCP (2007) and reported in U.S. EPA (2013)
Note: See attachment to the assessment's appendix for quantitative screening values.


Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 08/13/2021
Not determined

Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 08/13/2021
Not determined

Cancer Assessment

Weight of Evidence for CancerLast Updated: 08/13/2021
IN - Inadequate Information to Assess Carcinogenic Potential

Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 08/13/2021
Not determined

Estimate of Carcinogenic Risk from Inhalation ExposureLast Updated: 08/13/2021
Not determined

Provisional Peer-Reviewed Toxicity Values (PPRTVs)