Toluene-2,5-diamine
CASRN 95-70-5
PPRTV Toxicity Values Summary Table
Noncancer Assessment
Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 01/15/2013
See attachment to the assessment appendix for quantitative screening values. The calculated screening RfD of 3E-4 mg/kg-day for Toluene-2,5-diamine sulfate was multiplied by the ratio of molecular weights for Toluene-2,5-diamine (free base) to Toluene-2,5-diamine sulfate to obtain the screening RfD for Toluene-2,5-diamine (free base).
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 01/15/2013
See attachment to the assessment appendix for quantitative screening values. The calculated screening RfD of 3E-3 mg/kg-day for Toluene-2,5-diamine sulfate was multiplied by the ratio of molecular weights for Toluene-2,5-diamine (free base) to Toluene-2,5-diamine sulfate to obtain the screening RfD for Toluene-2,5-diamine (free base).
See attachment to the assessment appendix for quantitative screening values. The calculated screening RfD of 3E-4 mg/kg-day for Toluene-2,5-diamine sulfate was multiplied by the ratio of molecular weights for Toluene-2,5-diamine (free base) to Toluene-2,5-diamine sulfate to obtain the screening RfD for Toluene-2,5-diamine (free base).
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 01/15/2013
See attachment to the assessment appendix for quantitative screening values. The calculated screening RfD of 3E-3 mg/kg-day for Toluene-2,5-diamine sulfate was multiplied by the ratio of molecular weights for Toluene-2,5-diamine (free base) to Toluene-2,5-diamine sulfate to obtain the screening RfD for Toluene-2,5-diamine (free base).
Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 01/15/2013
Data are inadequate to derive a chronic RfC.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 01/15/2013
Data are inadequate to derive a subchronic RfC.
Data are inadequate to derive a chronic RfC.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 01/15/2013
Data are inadequate to derive a subchronic RfC.
Cancer Assessment
Weight of Evidence for CancerLast Updated: 01/15/2013
SU - Suggestive evidence of carcinogenic potential
Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 01/15/2013
See attachment to the assessment appendix for quantitative screening values. The BMDL-10HED used for the calculated screening oral slope factor of 1E-1 (mg/kg-day)-1 for Toluene-2,5-diamine sulfate was multiplied by the ratio of molecular weights for Toluene-2-5-Diamine to Toluene-2,5-diamine sulfate (122.17/220.25) to obtain the screening oral slope factor for Toluene-2-5-diamine (free-base).
SU - Suggestive evidence of carcinogenic potential
Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 01/15/2013
See attachment to the assessment appendix for quantitative screening values. The BMDL-10HED used for the calculated screening oral slope factor of 1E-1 (mg/kg-day)-1 for Toluene-2,5-diamine sulfate was multiplied by the ratio of molecular weights for Toluene-2-5-Diamine to Toluene-2,5-diamine sulfate (122.17/220.25) to obtain the screening oral slope factor for Toluene-2-5-diamine (free-base).