Provisional Peer-Reviewed Toxicity Values (PPRTVs)

Lithium

CASRN 7439-93-2

PPRTV Toxicity Values Summary Table

Noncancer Assessment

Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 06/12/2008
System RfD (mg/kg-day) Basis PoD UF Confidence
Other 2 x 10-3 Adverse effects LOAEL : 2.1 mg/kg-day 1000 Low/Medium
Species Studied: Human
Note: The lower bound of the therapeutic serum lithium concentration range was selected as the basis for the derivation.



Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 06/12/2008
System RfD (mg/kg-day) Basis PoD UF Confidence
Other 2 x 10-3 Adverse effects LOAEL : 2.1 mg/kg-day 1000 Low/Medium
Species Studied: Human
Note: The lower bound of the therapeutic serum lithium concentration range was selected as the basis for the derivation.



Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 06/12/2008
Data are inadequate to derive a chronic RfC.


Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 06/12/2008
Data are inadequate to derive a subchronic RfC.


Cancer Assessment

Weight of Evidence for CancerLast Updated: 06/12/2008
IN - Inadequate information to assess carcinogenic potential.

Provisional Peer-Reviewed Toxicity Values (PPRTVs)