Isopropanol
CASRN 67-63-0
PPRTV Toxicity Values Summary Table
Noncancer Assessment
Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/16/2014
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/16/2014
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Developmental | 2 | Decreased fetal body weight | BMDL05 : 55.2 mg/kg-day | 30 | Medium |
Species Studied: Rabbit
Duration: GD 6-18
Principal Study: Tyl et al. 1994
Note: The BMDL-05 of 120 mg/kg-day was converted to a HEC of 55.2 mg/kg-day.
Duration: GD 6-18
Principal Study: Tyl et al. 1994
Note: The BMDL-05 of 120 mg/kg-day was converted to a HEC of 55.2 mg/kg-day.
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/16/2014
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Developmental | 2 | Decreased fetal body weight | BMDL05 : 55.2 mg/kg-day | 30 | Medium |
Species Studied: Rabbit
Duration: GD 6-18
Principal Study: Tyl et al. 1994
Note: The BMDL-05 of 120 mg/kg-day was converted to a HEC of 55.2 mg/kg-day.
Duration: GD 6-18
Principal Study: Tyl et al. 1994
Note: The BMDL-05 of 120 mg/kg-day was converted to a HEC of 55.2 mg/kg-day.
Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 09/16/2014
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 09/16/2014
| System | RfC (mg/m3) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Endocrine | 2 x 10-1 | Decreased absolute and relative testes weights | LOAEL(HEC) : 221 mg/m3 | 1000 | Medium |
Species Studied: Mouse
Duration: 6 hr/d, 5 d/wk, at least 78 weeks
Principal Study: Burleigh-Flayer et al. 1997
Duration: 6 hr/d, 5 d/wk, at least 78 weeks
Principal Study: Burleigh-Flayer et al. 1997
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 09/16/2014
| System | RfC (mg/m3) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Whole Body Effects | 7 | Increased mean cumulative motor activity | NOAEL(HEC) : 662.3 mg/m3 | 100 | Medium |
Species Studied: Rat
Duration: 6 hr/d, 5 d/wk, 13 weeks
Principal Study: Burleigh-Flayer et al. 1994
Duration: 6 hr/d, 5 d/wk, 13 weeks
Principal Study: Burleigh-Flayer et al. 1994
Cancer Assessment
Weight of Evidence for CancerLast Updated: 09/16/2014
IN - Inadequate information to assess carcinogenic potential (oral, inhalation is not likely to be carcinogenic)
IN - Inadequate information to assess carcinogenic potential (oral, inhalation is not likely to be carcinogenic)