Ethyl Acrylate
CASRN 140-88-5
PPRTV Toxicity Values Summary Table
Noncancer Assessment
Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/17/2014
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/17/2014
See attachment to the assessment's appendix for quantitative screening values.
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Gastrointestinal | 5 x 10-3 | Increased incidence and severity of forestomach gross pathology, hyperplasia, and associated lesions. | BMDL10 : 1.6 mg/kg-day | 300 | Medium |
Species Studied: Rat
Duration: 5 d/wk, 103 weeks
Principal Study: NTP 1986
Note: The BMDL10 of 2.3 mg/kg-day was adjusted for continuous exposure.
Duration: 5 d/wk, 103 weeks
Principal Study: NTP 1986
Note: The BMDL10 of 2.3 mg/kg-day was adjusted for continuous exposure.
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/17/2014
See attachment to the assessment's appendix for quantitative screening values.
Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 09/17/2014
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 09/17/2014
| System | RfC (mg/m3) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Respiratory | 8 x 10-3 | Dose-dependent histopathological lesions of the olfactory tract, including respiratory metaplasia. | NOAEL(HEC) : 0.76 mg/m3 | 100 | Medium |
Species Studied: Rat
Duration: 6 hr/d, 5 d/wk, for 27 months
Principal Study: Miller et al. 1985
Note: Because the critical effect occurred at the portal of entry, and there were no appreciable changes in the extent and severity of lesions over time as the study progressed, the same toxicity value was estimated for both subchronic and chronic p-RfCs.
Duration: 6 hr/d, 5 d/wk, for 27 months
Principal Study: Miller et al. 1985
Note: Because the critical effect occurred at the portal of entry, and there were no appreciable changes in the extent and severity of lesions over time as the study progressed, the same toxicity value was estimated for both subchronic and chronic p-RfCs.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 09/17/2014
| System | RfC (mg/m3) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Respiratory | 8 x 10-3 | Dose-dependent histopathological lesions of the olfactory tract, including respiratory metaplasia. | NOAEL(HEC) : 0.76 mg/m3 | 100 | Medium |
Species Studied: Rat
Duration: 6 hr/d, 5 d/wk, for 27 months
Principal Study: Miller et al. 1985
Note: Because the critical effect occurred at the portal of entry, and there were no appreciable changes in the extent and severity of lesions over time as the study progressed, the same toxicity value was estimated for both subchronic and chronic p-RfCs.
Duration: 6 hr/d, 5 d/wk, for 27 months
Principal Study: Miller et al. 1985
Note: Because the critical effect occurred at the portal of entry, and there were no appreciable changes in the extent and severity of lesions over time as the study progressed, the same toxicity value was estimated for both subchronic and chronic p-RfCs.
Cancer Assessment
Weight of Evidence for CancerLast Updated: 09/17/2014
SU - Suggestive evidence of carcinogenic potential (oral. Inhalation is not likely to be carcinogenic)
Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 09/17/2014
Data are inadequate to derive an oral slope factor.
SU - Suggestive evidence of carcinogenic potential (oral. Inhalation is not likely to be carcinogenic)
Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 09/17/2014
Data are inadequate to derive an oral slope factor.