Provisional Peer-Reviewed Toxicity Values (PPRTVs)

1,1-Dimethylhydrazine

CASRN 57-14-7

PPRTV Toxicity Values Summary Table

Noncancer Assessment

Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/30/2009
See attachment to the assessment's appendix for quantitative screening values.


Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/30/2009
Data are inadequate to derive a subchronic RfD.



Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 09/30/2009
See attachment to the assessment's appendix for quantitative screening values.


Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 09/30/2009
System RfC (mg/m3) Basis PoD UF Confidence
Reproductive 8 x 10-6 Endometrial cysts LOAEL : 0.023 mg/m3 3000 Low
Species Studied: Mouse
Duration: 6 months
Principal Study: Haun et al. 1979, 1984


Cancer Assessment

Weight of Evidence for CancerLast Updated: 09/30/2009
LI - Likely to be carcinogenic to humans.


Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 09/30/2009
Data are inadequate to derive an oral slope factor.


Estimate of Carcinogenic Risk from Inhalation ExposureLast Updated: 09/30/2009
Data are inadequate to derive an inhalation unit risk.

Provisional Peer-Reviewed Toxicity Values (PPRTVs)