N,N-Dimethylaniline
CASRN 121-69-7
PPRTV Toxicity Values Summary Table
Noncancer Assessment
Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 08/11/2016
Please see IRIS.
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 08/11/2016
Please see IRIS.
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 08/11/2016
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Immune | 2 x 10-3 | Extramedullary hematopoiesis and hemosiderosis | LOAEL : 5.3 mg/kg-day | 3000 | Low |
Species Studied: Rat
Duration: 5 d/wk, 13 weeks
Principal Study: Abdo et al. 1990, NTP 1989
Note: The LOAEL of 22.32 mg/kg-day was converted to a Human Equivalent Dose (HED) of 5.3 mg/kg-day.
Duration: 5 d/wk, 13 weeks
Principal Study: Abdo et al. 1990, NTP 1989
Note: The LOAEL of 22.32 mg/kg-day was converted to a Human Equivalent Dose (HED) of 5.3 mg/kg-day.
Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 08/11/2016
Data are inadequate to derive a chronic RfC.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 08/11/2016
Data are inadequate to derive a subchronic RfC.
Data are inadequate to derive a chronic RfC.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 08/11/2016
Data are inadequate to derive a subchronic RfC.
Cancer Assessment
Weight of Evidence for CancerLast Updated: 08/11/2016
SU - Suggestive evidence of carcinogenic potential for oral exposure. Inadequate information for inhalation.
Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 08/11/2016
Oral Slope Factor: 2.7 x 10-2 per mg/kg-day
Tumor site(s):
Cancer: sarcoma or osteosarcoma
Species Studied: Rat
Duration: 5 d/wk, 103 weeks
Principal Study: NTP 1989
Note:
Estimate of Carcinogenic Risk from Inhalation ExposureLast Updated: 08/11/2016
Data are inadequate to derive an inhalation unit risk.
SU - Suggestive evidence of carcinogenic potential for oral exposure. Inadequate information for inhalation.
Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 08/11/2016
Oral Slope Factor: 2.7 x 10-2 per mg/kg-day
Tumor site(s):
Cancer: sarcoma or osteosarcoma
Species Studied: Rat
Duration: 5 d/wk, 103 weeks
Principal Study: NTP 1989
Note:
Estimate of Carcinogenic Risk from Inhalation ExposureLast Updated: 08/11/2016
Data are inadequate to derive an inhalation unit risk.