3,3'-Dimethoxybenzidine
CASRN 119-90-4
PPRTV Toxicity Values Summary Table
Noncancer Assessment
Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 06/12/2013
Data are inadequate to derive a chronic or subchronic RfD.
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 06/12/2013
See attachment to the assessment's appendix for quantitative screening values.
Data are inadequate to derive a chronic or subchronic RfD.
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 06/12/2013
See attachment to the assessment's appendix for quantitative screening values.
Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 06/12/2013
Data are inadequate to derive a chronic or subchronic RfC.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 06/12/2013
Data are inadequate to derive a subchronic RfC.
Data are inadequate to derive a chronic or subchronic RfC.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 06/12/2013
Data are inadequate to derive a subchronic RfC.
Cancer Assessment
Weight of Evidence for CancerLast Updated: 06/12/2013
LI - Likely to be carcinogenic to humans
Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 06/12/2013
Oral Slope Factor: 1.6 per mg/kg-day
Tumor site(s):
Cancer: Combined incidence for hepatocellular carcinomas
Species Studied: Rat
Duration: 21 months
Principal Study: NTP 1990
Note: An adjustment factor (L/Le)^3 was applied for the shorter-than-lifetime duration. NOTE: For chemicals that have been determined to be carcinogenic by a mutagenic mode of action, sample calculations for estimation of risk are supplied in the Supplementary Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens, March, 2005, especially Example 2, which presents a sample calculation for a total lifetime exposure (0-70 years). Both the exposure and the increased potency in early life exposures must be utilized by the risk assessor in the field to determine risk. For oral exposure (OSF), the dose (Dose= Intake Rate x Concentration in media / Body Weight; e.g. mg/kg-day; Risk = Dose x ADAF x Duration factor x OSF) must be calculated for each age bracket (0-<2, 2-<16, and 16-70 years). The dose for each life stage is utilized to determine risk as indicated above using the appropriate ADAF (10, 3, 1), and duration factor (2/70, 13/70 and 55/70). The Exposure Factors Handbook indicates that the average weight for human male and female in the age bracket of 0-<2 is 7.6 Kg, for 2-<16 is 36.4 Kg and for 16-70 is 70Kg. Intake rates for each life stage and concentrations in the media must be determined by the risk assessor in the field.
LI - Likely to be carcinogenic to humans
Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 06/12/2013
Oral Slope Factor: 1.6 per mg/kg-day
Tumor site(s):
Cancer: Combined incidence for hepatocellular carcinomas
Species Studied: Rat
Duration: 21 months
Principal Study: NTP 1990
Note: An adjustment factor (L/Le)^3 was applied for the shorter-than-lifetime duration. NOTE: For chemicals that have been determined to be carcinogenic by a mutagenic mode of action, sample calculations for estimation of risk are supplied in the Supplementary Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens, March, 2005, especially Example 2, which presents a sample calculation for a total lifetime exposure (0-70 years). Both the exposure and the increased potency in early life exposures must be utilized by the risk assessor in the field to determine risk. For oral exposure (OSF), the dose (Dose= Intake Rate x Concentration in media / Body Weight; e.g. mg/kg-day; Risk = Dose x ADAF x Duration factor x OSF) must be calculated for each age bracket (0-<2, 2-<16, and 16-70 years). The dose for each life stage is utilized to determine risk as indicated above using the appropriate ADAF (10, 3, 1), and duration factor (2/70, 13/70 and 55/70). The Exposure Factors Handbook indicates that the average weight for human male and female in the age bracket of 0-<2 is 7.6 Kg, for 2-<16 is 36.4 Kg and for 16-70 is 70Kg. Intake rates for each life stage and concentrations in the media must be determined by the risk assessor in the field.