Diethylene Glycol Monomethyl Ether
CASRN 111-77-3
PPRTV Toxicity Values Summary Table
Noncancer Assessment
Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/29/2015
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/29/2015
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Developmental | 4 x 10-2 | Thymic remnants, dilation of renal pelvis and reduced ossification in fetal rats | BMDL05 : 12 mg/kg-day | 300 | Low |
Species Studied: Rat
Duration: GD 7-16
Principal Study: Yamano et al. 1993, Hardin et al. 1986
Note: The POD for development effects used to derive a subchronic RfD is also used for the chronic RfD.
Duration: GD 7-16
Principal Study: Yamano et al. 1993, Hardin et al. 1986
Note: The POD for development effects used to derive a subchronic RfD is also used for the chronic RfD.
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/29/2015
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Developmental | 4 x 10-2 | Thymic remnants, dilation of renal pelvis and reduced ossification in fetal rats | BMDL05 : 12 mg/kg-day | 300 | Low |
Species Studied: Rat
Duration: GD 7-16
Principal Study: Yamano et al. 1993, Hardin et al. 1986
Duration: GD 7-16
Principal Study: Yamano et al. 1993, Hardin et al. 1986
Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 09/29/2015
Data are inadequate to derive a chronic or subchronic RfC.
Data are inadequate to derive a chronic or subchronic RfC.
Cancer Assessment
Weight of Evidence for CancerLast Updated: 09/29/2015
IN - Inadequate information to assess carcinogenic potential
IN - Inadequate information to assess carcinogenic potential