1,3-Dichloropropane
CASRN 142-28-9
PPRTV Toxicity Values Summary Table
Noncancer Assessment
Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 03/01/2006
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 03/01/2006
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Hepatic , Urinary |
2 x 10-2 | histopathological lesions, increased weight histopathological lesions, increased weight |
NOAEL : 50 mg/kg-day | 3000 | Low/Medium |
Species Studied: Rat
Duration: 90 days
Principal Study: Terrill et al. 1991
Note: There is also a LOAEL associated with this value.
Duration: 90 days
Principal Study: Terrill et al. 1991
Note: There is also a LOAEL associated with this value.
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 03/01/2006
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Urinary , Hepatic |
2 x 10-1 | histopathological lesions, increased weight histopathological lesions, increased weight |
NOAEL : 50 mg/kg-day | 300 | Low/Medium |
Species Studied: Rat
Duration: 90 days
Principal Study: Terrill et al. 1991
Note: There is also a LOAEL value with this study.
Duration: 90 days
Principal Study: Terrill et al. 1991
Note: There is also a LOAEL value with this study.
Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 03/01/2006
Data inadequate for deriving a chronic RfC.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 03/01/2006
Data inadequate for deriving a subchronic RfC.
Data inadequate for deriving a chronic RfC.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 03/01/2006
Data inadequate for deriving a subchronic RfC.
Cancer Assessment
Weight of Evidence for CancerLast Updated: 03/01/2006
IN - Inadequate information to assess carcinogenic potential
IN - Inadequate information to assess carcinogenic potential