1,2-Dibromo-3-Chloropropane
CASRN 96-12-8
PPRTV Toxicity Values Summary Table
Noncancer Assessment
Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 08/03/2006
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 08/03/2006
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Endocrine | 2 x 10-4 | Testicular effects | NOAEL : 0.7 mg/kg-day | 3000 | Medium |
Species Studied: Rabbit
Duration: 10 weeks
Principal Study: Foote et al. 1986
Note: The RfD was derived from the subchronic study. There is also a LOAEL associated with this value.
Duration: 10 weeks
Principal Study: Foote et al. 1986
Note: The RfD was derived from the subchronic study. There is also a LOAEL associated with this value.
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 08/03/2006
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Endocrine | 2 x 10-3 | Testicular effects | NOAEL : 0.7 mg/kg-day | 300 | Medium |
Species Studied: Rabbit
Duration: 10 weeks
Principal Study: Foote et al. 1986
Note: There is also a LOAEL value with this study.
Duration: 10 weeks
Principal Study: Foote et al. 1986
Note: There is also a LOAEL value with this study.
Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 08/03/2006
Please see IRIS.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 08/03/2006
Please see IRIS.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 08/03/2006
| System | RfC (mg/m3) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Endocrine | 2 x 10-3 | Testicular effects | NOAEL : 0.17 mg/m3 | 100 | Medium |
Species Studied: Rabbit
Duration: 14 weeks
Principal Study: Rao et al. 1982
Note: The NOAEL was adjusted from 0.94 mg/m3 to account for intermittent exposure.
Duration: 14 weeks
Principal Study: Rao et al. 1982
Note: The NOAEL was adjusted from 0.94 mg/m3 to account for intermittent exposure.
Cancer Assessment
Weight of Evidence for CancerLast Updated: 08/03/2006
LI - Likely to be carcinogenic to humans
Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 08/03/2006
Oral Slope Factor: 8 x 10-1 per mg/kg-day
Tumor site(s):
Cancer: Renal tubular cell adenoma or carcinoma
Species Studied: Rat
Duration: 104 weeks
Principal Study: Hazelton Laboratories 1977
Note: For chemicals that have been determined to be carcinogenic by a mutagenic mode of action, sample calculations for estimation of risk are supplied in the Supplementary Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens, March, 2005, especially Example 2, which presents a sample calculation for a total lifetime exposure (0-70 years). Both the exposure and the increased potency in early life exposures must be utilized by the risk assessor in the field to determine risk. For oral exposure (OSF), the dose (Dose= Intake Rate x Concentration in media / Body Weight; e.g. mg/kg-day; Risk = Dose x ADAF x Duration factor x OSF) must be calculated for each age bracket (0-<2, 2-<16, and 16-70 years). The dose for each life stage is utilized to determine risk as indicated above using the appropriate ADAF (10, 3, 1), and duration factor (2/70, 13/70 and 55/70). The Exposure Factors Handbook indicates that the average weight for human male and female in the age bracket of 0-<2 is 7.6 Kg, for 2-<16 is 36.4 Kg and for 16-70 is 70Kg. Intake rates for each life stage and concentrations in the media must be determined by the risk assessor in the field.
Estimate of Carcinogenic Risk from Inhalation ExposureLast Updated: 08/03/2006
Unit Risk Factor: 6 per mg/m3
Tumor site(s):
Cancer: Tumors
Species Studied: Rat
Duration: 105-107, 103, or 84 weeks
Principal Study: NTP 1982
Note: Based on the BMC10. For chemicals that have been determined to be carcinogenic by a mutagenic mode of action, sample calculations for estimation of risk are supplied in the Supplementary Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens, March, 2005, especially Example 2 which presents a sample calculation for a total lifetime exposure (0-70 years). Both the exposure and the increased potency in early life exposures must be utilized by the risk assessor in the field to determine risk. For inhalation; (IUR), Risk = IUR x ADAF x Exposure Concentration x Duration Factor , which is independent of intake rates and body weights, the ADAFs are applied according to the exposure concentration (e.g. mg chemical/cubic meter) and duration factor in each age category, viz. 0<2 years, 2<16 years using a 10 fold and 3 fold factor, respectively, times the IUR , and greater than 16 years with no additional factor, taking into account the time of exposure relative to a 70 year lifetime. For example an exposure in the 0-2 year category, would be calculated as (exposure concentration x 10 x 2/70 years x IUR); for the 2-16 years (exposure concentration x 3 x 13/70 years x IUR), and finally for greater than 16 years (exposure concentration x 1 x 55/70 x IUR). Exposure concentrations must be determined for each life stage. The lifetime risk is the sum of the individual risks at each life stage. If the exposure concentrations are the same at each life stage, the lifetime risk would be; Exposure Concentration x 1.6 x IUR, i.e. a 60% greater susceptibility from a whole life exposure (from birth.)
LI - Likely to be carcinogenic to humans
Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 08/03/2006
Oral Slope Factor: 8 x 10-1 per mg/kg-day
Tumor site(s):
Cancer: Renal tubular cell adenoma or carcinoma
Species Studied: Rat
Duration: 104 weeks
Principal Study: Hazelton Laboratories 1977
Note: For chemicals that have been determined to be carcinogenic by a mutagenic mode of action, sample calculations for estimation of risk are supplied in the Supplementary Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens, March, 2005, especially Example 2, which presents a sample calculation for a total lifetime exposure (0-70 years). Both the exposure and the increased potency in early life exposures must be utilized by the risk assessor in the field to determine risk. For oral exposure (OSF), the dose (Dose= Intake Rate x Concentration in media / Body Weight; e.g. mg/kg-day; Risk = Dose x ADAF x Duration factor x OSF) must be calculated for each age bracket (0-<2, 2-<16, and 16-70 years). The dose for each life stage is utilized to determine risk as indicated above using the appropriate ADAF (10, 3, 1), and duration factor (2/70, 13/70 and 55/70). The Exposure Factors Handbook indicates that the average weight for human male and female in the age bracket of 0-<2 is 7.6 Kg, for 2-<16 is 36.4 Kg and for 16-70 is 70Kg. Intake rates for each life stage and concentrations in the media must be determined by the risk assessor in the field.
Estimate of Carcinogenic Risk from Inhalation ExposureLast Updated: 08/03/2006
Unit Risk Factor: 6 per mg/m3
Tumor site(s):
Cancer: Tumors
Species Studied: Rat
Duration: 105-107, 103, or 84 weeks
Principal Study: NTP 1982
Note: Based on the BMC10. For chemicals that have been determined to be carcinogenic by a mutagenic mode of action, sample calculations for estimation of risk are supplied in the Supplementary Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens, March, 2005, especially Example 2 which presents a sample calculation for a total lifetime exposure (0-70 years). Both the exposure and the increased potency in early life exposures must be utilized by the risk assessor in the field to determine risk. For inhalation; (IUR), Risk = IUR x ADAF x Exposure Concentration x Duration Factor , which is independent of intake rates and body weights, the ADAFs are applied according to the exposure concentration (e.g. mg chemical/cubic meter) and duration factor in each age category, viz. 0<2 years, 2<16 years using a 10 fold and 3 fold factor, respectively, times the IUR , and greater than 16 years with no additional factor, taking into account the time of exposure relative to a 70 year lifetime. For example an exposure in the 0-2 year category, would be calculated as (exposure concentration x 10 x 2/70 years x IUR); for the 2-16 years (exposure concentration x 3 x 13/70 years x IUR), and finally for greater than 16 years (exposure concentration x 1 x 55/70 x IUR). Exposure concentrations must be determined for each life stage. The lifetime risk is the sum of the individual risks at each life stage. If the exposure concentrations are the same at each life stage, the lifetime risk would be; Exposure Concentration x 1.6 x IUR, i.e. a 60% greater susceptibility from a whole life exposure (from birth.)