4-Chloro-2-methylaniline
CASRN 95-69-2
PPRTV Toxicity Values Summary Table
Noncancer Assessment
Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/30/2010
See attachment to the assessment's appendix for quantitative screening values.
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/30/2010
See attachment to the assessment's appendix for quantitative screening values.
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 09/30/2010
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Whole Body Effects | 5 x 10-1 | Decreased body weight changes in females | NOAEL : 677 mg/kg-day | 1000 | Medium |
Species Studied: Rat
Duration: 7 weeks
Principal Study: NCI 1979
Note: Because the study administered 4-chloro-2-methylaniline hydrochloride, the subchronic RfD is converted to reflect the molecular weight difference between 4-chloro-2-methylamiline and the salt form.
Duration: 7 weeks
Principal Study: NCI 1979
Note: Because the study administered 4-chloro-2-methylaniline hydrochloride, the subchronic RfD is converted to reflect the molecular weight difference between 4-chloro-2-methylamiline and the salt form.
Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 09/30/2010
Data are inadequate to derive a chronic RfC.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 09/30/2010
Data are inadequate to derive a subchronic RfC.
Data are inadequate to derive a chronic RfC.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 09/30/2010
Data are inadequate to derive a subchronic RfC.
Cancer Assessment
Weight of Evidence for CancerLast Updated: 09/30/2010
LI - Likely to be carcinogenic to humans
Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 09/30/2010
Oral Slope Factor: 1 x 10-1 per mg/kg-day
Tumor site(s):
Cancer: Hemangiosarcoma or hemangioma
Species Studied: Mouse
Duration: 18 months
Principal Study: Weisburger et al. 1978
Note: Because the study administered 4-chloro-2-methylaniline hydrochloride, the oral slope factor is converted to reflect the molecular weight difference between 4-chloro-2-methylamiline and the salt form.
Estimate of Carcinogenic Risk from Inhalation ExposureLast Updated: 09/30/2010
Data are inadequate to derive an inhalation unit risk.
LI - Likely to be carcinogenic to humans
Estimate of Carcinogenic Risk from Oral ExposureLast Updated: 09/30/2010
Oral Slope Factor: 1 x 10-1 per mg/kg-day
Tumor site(s):
Cancer: Hemangiosarcoma or hemangioma
Species Studied: Mouse
Duration: 18 months
Principal Study: Weisburger et al. 1978
Note: Because the study administered 4-chloro-2-methylaniline hydrochloride, the oral slope factor is converted to reflect the molecular weight difference between 4-chloro-2-methylamiline and the salt form.
Estimate of Carcinogenic Risk from Inhalation ExposureLast Updated: 09/30/2010
Data are inadequate to derive an inhalation unit risk.