Boron Trichloride
CASRN 10294-34-5
PPRTV Toxicity Values Summary Table
Noncancer Assessment
Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 11/06/2012
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 11/06/2012
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Developmental | 2 | Decreased fetal weight | BMDL05 : 10.3 mg/kg-day | 66 | High |
Species Studied: Rat
Duration: GD 0-20
Principal Study: Price et al. 1996a; Heindel et al. 1992, 1994
Note: Based on the IRIS RfD for Boron and Compounds, adjusted using the boron trichloride-to-boron molecular weight ration of 117.17/10.81 g/mol
Duration: GD 0-20
Principal Study: Price et al. 1996a; Heindel et al. 1992, 1994
Note: Based on the IRIS RfD for Boron and Compounds, adjusted using the boron trichloride-to-boron molecular weight ration of 117.17/10.81 g/mol
Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 11/06/2012
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Developmental | 2 | Decreased fetal weight | BMDL05 : 10.3 mg/kg-day | 66 | High |
Species Studied: Rat
Duration: GD 0-20
Principal Study: Price et al. 1996a; Heindel et al. 1992, 1994
Note: Based on the IRIS RfD for Boron and Compounds, adjusted using the boron trichloride-to-boron molecular weight ration of 117.17/10.81 g/mol
Duration: GD 0-20
Principal Study: Price et al. 1996a; Heindel et al. 1992, 1994
Note: Based on the IRIS RfD for Boron and Compounds, adjusted using the boron trichloride-to-boron molecular weight ration of 117.17/10.81 g/mol
Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 11/06/2012
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 11/06/2012
| System | RfC (mg/m3) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Respiratory , Respiratory |
2 x 10-2 | Hyperplasia Hyperplasia |
LOAEL(HEC) : 6.1 mg/m3 | 300 | Low |
Species Studied: Rat
Duration: 6 hr/d, 5 d/wk, for lifetime
Principal Study: Albert et al. 1982; Sellakumar et al. 1985
Note: Based on the IRIS RfD for Hydrogen chloride, adjusted using the boron trichloride-HCl molecular weight ration of 117.17/36.46 g/mol and the 3:1 molecular hydrolysis rate.
Duration: 6 hr/d, 5 d/wk, for lifetime
Principal Study: Albert et al. 1982; Sellakumar et al. 1985
Note: Based on the IRIS RfD for Hydrogen chloride, adjusted using the boron trichloride-HCl molecular weight ration of 117.17/36.46 g/mol and the 3:1 molecular hydrolysis rate.
Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 11/06/2012
| System | RfC (mg/m3) | Basis | PoD | UF | Confidence |
|---|---|---|---|---|---|
| Respiratory , Respiratory |
2 x 10-2 | Hyperplasia Hyperplasia |
LOAEL(HEC) : 6.1 mg/m3 | 300 | Low |
Species Studied: Rat
Duration: 6 hr/d, 5 d/wk, for lifetime
Principal Study: Albert et al. 1982; Sellakumar et al. 1985
Note: Based on the IRIS RfD for Hydrogen chloride, adjusted using the boron trichloride-HCl molecular weight ration of 117.17/36.46 g/mol and the 3:1 molecular hydrolysis rate.
Duration: 6 hr/d, 5 d/wk, for lifetime
Principal Study: Albert et al. 1982; Sellakumar et al. 1985
Note: Based on the IRIS RfD for Hydrogen chloride, adjusted using the boron trichloride-HCl molecular weight ration of 117.17/36.46 g/mol and the 3:1 molecular hydrolysis rate.
Cancer Assessment
Weight of Evidence for CancerLast Updated: 11/06/2012
IN - Inadequate for an assessment of carcinogenic potential
IN - Inadequate for an assessment of carcinogenic potential