p-Aminophenol

Provisional Peer-Reviewed Toxicity Values (PPRTVs)

CASRN 123-30-8

Provisional Peer-Reviewed Toxicity Values for Aminophenol, p-

PPRTV Toxicity Values Summary Table

Noncancer Assessment

Estimate of Chronic Reference Dose for Oral Exposure (RfD)Last Updated: 08/08/2005

System	RfD (mg/kg-day)	Basis	PoD	UF	Confidence
Urinary	2 x 10^-2	Tubular necrosis, increased levels of enzymes indicative of renal failure, measures of impaired renal function	NOAEL : 50 mg/kg-day	3000	Low

Species Studied: Rat
Duration: 13 weeks
Principal Study: Burnett el al 1989

Estimate of Subchronic Reference Dose for Oral Exposure (RfD)Last Updated: 08/08/2005

System	RfD (mg/kg-day)	Basis	PoD	UF	Confidence
Urinary	2 x 10^-1	Tubular necrosis, increased levels of enzymes indicative of renal failure, measures of impaired renal function	NOAEL : 50 mg/kg-day	300	Low

Species Studied: Rat
Duration: 13 weeks
Principal Study: Burnett el al 1989

Estimate of Chronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 08/08/2005
Data inadequate for deriving a chronic RfC.

Estimate of Subchronic Reference Concentration for Inhalation Exposure (RfC)Last Updated: 08/08/2005
Data inadequate for deriving a subchronic RfC.