Integrated Science Assessment (ISA) for Lead (External Review Draft, 2023)
Notice - This site contains archived material(s)
Archive disclaimer
Archive
disclaimer
Archived files are provided for reference
purposes only. These files are no longer maintained by the Agency and may be outdated. For
current EPA information, go to www.epa.gov. It is EPA's policy to
support reasonable accommodation to persons with disabilities, pursuant to the Rehabilitation
Act of 1973, 29 U.S.C. 791. If you need assistance with accessing archived files, contact
EPA's Reasonable Accommodations
or submit a request using the Contact Us form.
Abstract
EPA announced that an external review draft of the Integrated Science Assessment (ISA) for Lead (Pb) was made available for independent peer review and public comment. This draft ISA represents a concise synthesis and evaluation of the most policy-relevant science and will ultimately provide the scientific bases for EPA’s decision regarding whether the current standards for Pb sufficiently protect public health and the environment.
As part of the current Lead (Pb) NAAQS review, EPA prepared this draft Pb Integrated Science Assessment (ISA) and released it for public comment and peer review by the Clean Air Scientific Advisory Committee (CASAC). This document is an external review draft for peer review purposes only. This information is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by the EPA. It does not represent, and should not be construed to represent, any Agency determination or policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. This draft ISA consists of the Front Matter (list of authors, contributors, and reviewers), Executive Summary, Integrated Synthesis, and 12 appendices.
As part of the current Lead (Pb) NAAQS review, EPA prepared this draft Pb Integrated Science Assessment (ISA) and released it for public comment and peer review by the Clean Air Scientific Advisory Committee (CASAC). This document is an external review draft for peer review purposes only. This information is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by the EPA. It does not represent, and should not be construed to represent, any Agency determination or policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. This draft ISA consists of the Front Matter (list of authors, contributors, and reviewers), Executive Summary, Integrated Synthesis, and 12 appendices.
Impact/Purpose
EPA is preparing to release the External Review Draft of the Integrated Science Assessment (ISA) for Lead (Pb) for public comment and peer review. The Clean Air Act (CAA) requires the United States Environmental Protection Agency (U.S. EPA) to set National Ambient Air Quality Standards (NAAQS) for criteria air pollutants, including lead (Pb), that are considered harmful to public health and the environment, and to periodically review the science upon which the NAAQS are based. When final, the ISA will represent the Agency’s latest evaluation of the scientific literature on relationships between Pb exposure and health and welfare effects.
Status
Following the external peer review the assessment will be finalized and posted on the EPA website.
Citation
U.S. EPA. Integrated Science Assessment (ISA) for Lead (External Review Draft, 2023). U.S. Environmental Protection Agency, Washington, DC, EPA/600/R‑23/061, 2023.
History/Chronology
| Date | Description |
|---|---|
| Jul 2020 | EPA announced a call for scientific research studies and data to assist EPA in developing and refining the scientific information base for the review of the Pb National Ambient Air Quality Standards (NAAQS). [Federal Register July 7, 2020] |
| Apr 2022 | The CASAC Lead Review Panel held a public meeting to provide a consultation on EPA's Integrated Review Plan for the Lead National Ambient Air Quality Standards (IRP). Volume 2: Planning for the Review and the Integrated Science Assessment. [Federal Register March 21, 2022] |
| May 2022 | EPA held a series of webinar workshops to obtain input on preliminary draft materials for the Pb ISA on May 26, June 7, June 22, and June 29, 2022. [Federal Register May 6, 2022] |
| Mar 2023 | EPA released the document Integrated Science Assessment for Lead (External Review Draft, 2023) for public review and comment. [Federal Register March 31, 2023] |
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Front Matter, Executive Summary, and Integrative Synthesis (PDF) (149 pp, 2 MB, about PDF)
- Appendix 1. Lead Source to Concentration (PDF) (88 pp, 1 MB, about PDF)
- Appendix 2. Exposure, Toxicokinetics, and Biomarkers (PDF) (164 pp, 2 MB, about PDF)
- Appendix 3. Nervous System Effects (PDF) (541 pp, 6 MB, about PDF)
- Appendix 4. Cardiovascular Effects (PDF) (173 pp, 3 MB, about PDF)
- Appendix 5. Renal Effects (PDF) (89 pp, 2 MB, about PDF)
- Appendix 6. Immune System Effects (PDF) (90 pp, 1 MB, about PDF)
- Appendix 7. Hematological Effects (PDF) (44 pp, 891 KB, about PDF)
- Appendix 8. Reproductive and Developmental Effects (PDF) (266 pp, 2 MB, about PDF)
- Appendix 9. Effects on Other Organ Systems and Mortality (PDF) (166 pp, 2 MB, about PDF)
- Appendix 10. Cancer (PDF) (53 pp, 3 MB, about PDF)
- Appendix 11. Effects of Lead in Terrestrial and Aquatic Ecosystems (PDF) (257 pp, 7 MB, about PDF)
- Appendix 12. Process for Developing the Pb Integrated Science Assessment (PDF) (40 pp, 929 KB, about PDF)
- PEER REVIEW CHARGE (PDF) (5 pp, 287 KB, about PDF)
- CASAC REVIEW OF THE EPA’S INTEGRATED SCIENCE ASSESSMENT (ISA) FOR LEAD (EXTERNAL REVIEW DRAFT – MARCH 2023) (PDF) (130 pp, 2 MB, about PDF)
- EPA-CASAC-23-003 RESPONSE-REV (PDF) (5 pp, 300 KB, about PDF)
Related Link(s)
Docket
Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2020-0701