Integrated Science Assessment (ISA) for Oxides of Nitrogen – Health Criteria (Second External Review Draft, 2015)
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The references considered for inclusion in or cited in the first and second external review drafts of the ISA are available at https://hero.epa.gov/oxides-of-nitrogen.
Oxides of nitrogen are one of six principal (or criteria) pollutants for which EPA has established national ambient air quality standards (NAAQS). For oxides of nitrogen, the NAAQS are specified in terms of nitrogen dioxide (NO2). The Clean Air Act requires EPA to periodically review the scientific basis for these standards by preparing an Integrated Science Assessment. These reviews play a significant role in EPA’s commitment to ensuring a clean and healthy environment for the public.
The second draft ISA is part of the Agency’s periodic review of the primary (health-based) NAAQS for NO2. Overall, findings from recent studies strengthen the conclusions from the previous NAAQS review, which was completed in 2010. Results from recent studies strengthen the body of evidence indicating that short-term exposure to NO2 can cause respiratory effects, in particular, effects related to asthma exacerbation. Recent results also strengthen the evidence that the respiratory effects of short-term NO2 exposure are independent of the effects of many other traffic-related pollutants. There is now stronger evidence for a relationship between long-term exposure to NO2 and respiratory effects, particularly the development of asthma in children. Results suggest that short-term exposure to NO2 may be associated with cardiovascular effects and related metabolic effects and premature mortality and that long-term exposure may be associated with cardiovascular and related metabolic effects, poorer birth outcomes, premature mortality, and cancer; however, it is uncertain whether these effects of NO2 exposure are independent from the effects of other traffic-related pollutants.
|Jul 2008||EPA released the Integrated Science Assessment for Oxides of Nitrogen – Health Criteria (Final Report) (EPA/600/R-08/071). [Federal Register Notice Jul 11, 2008]|
|Mar 2012||EPA held a workshop entitled "Kickoff Workshop to Inform EPA's Review of the Primary NO2 NAAQS'" co-organized by EPA/ORD/NCEA and the EPA/OAQPS Staff to help with the development of future products on this subject matter. The workshop was held February 29 - March 1, 2012, in Research Triangle Park, North Carolina. [Federal Register Notice Feb 10, 2012]|
|May 2013||EPA released the Draft Plan for the Development of the Integrated Science Assessment for Oxides of Nitrogen - Health Criteria. [Federal Register Notice May 3, 2013]|
|Jun 2013||EPA's Science Advisory Board's CASAC announces a June 2013 consultation by the Oxides of Nitrogen Review Panel on the draft plan. [Federal Register Notice May 9, 2013]|
|Jun 2013||EPA held a public workshop to review initial draft materials to inform the development of the upcoming development of the Integrated Science Assessment for Oxides of Nitrogen – Health Criteria. [Federal Register Notice May 10, 2013]|
|Nov 2013||EPA released the Integrated Science Assessment for Oxides of Nitrogen – Health Criteria (First External Review Draft) for public review and comment. [Federal Register Notice Nov 22, 2013]|
|Mar 2014||EPA's Science Advisory Board's CASAC announced a meeting for the Oxides of Nitrogen Review Panel regarding the review of the first external review draft. [Federal Register Notice Feb 13, 2014]|
|Jan 2015||EPA released the Integrated Science Assessment for Oxides of Nitrogen – Health Criteria (Second External Review Draft) for public review and comment. [Federal Register Notice Jan 30, 2015]|
|Mar 2015||EPA announced an extension of the public comment period until April 30, 2015. [Federal Register Notice Mar 20, 2015 ]|
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.