Integrated Science Assessment (ISA) for Oxides of Nitrogen – Health Criteria (First External Review Draft, 2013)
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Oxides of nitrogen are one of six principal (or criteria) pollutants for which EPA has established national ambient air quality standards (NAAQS). For oxides of nitrogen, the NAAQS are specified in terms of nitrogen dioxide (NO2). The Clean Air Act requires EPA to periodically review the scientific basis for these standards by preparing an Integrated Science Assessment. These reviews play a significant role in EPA’s commitment to ensuring a clean and healthy environment for the public.
The first draft ISA is part of the Agency’s periodic review of the primary (health-based) NAAQS for NO2. Overall, findings from recent studies strengthen the conclusions from the previous NAAQS review, which was completed in 2010. Results from recent studies strengthen the body of evidence indicating that short-term exposure to NO2 can cause respiratory effects, in particular, effects related to asthma exacerbations. Recent results also strengthen the evidence that the respiratory effects of NO2 are independent of the effects of many other traffic-related pollutants. And finally, recent results expand on previous results supporting relationships between short-term exposure to NO2 and cardiovascular effects and premature mortality. There is now stronger evidence for a relationship between long-term exposure to NO2 and respiratory effects, particularly in children.
|EPA released the Integrated Science Assessment for Oxides of Nitrogen – Health Criteria (Final Report) (EPA/600/R-08/071). [Federal Register Notice Jul 11, 2008]
|EPA held a workshop entitled "Kickoff Workshop to Inform EPA's Review of the Primary NO2 NAAQS'" co-organized by EPA/ORD/NCEA and the EPA/OAQPS Staff to help with the development of future products on this subject matter. The workshop was held February 29 - March 1, 2012, in Research Triangle Park, North Carolina. [Federal Register Notice Feb 10, 2012]
|EPA released the draft development plan for the next Integrated Science Assessment (ISA) for health effects of oxides of nitrogen. [Federal Register Notice May 3, 2013]
|EPA's Science Advisory Board's CASAC announces a June 2013 consultation by the Oxides of Nitrogen Review Panel on the Draft Plan for the Development of the Integrated Science Assessment for Oxides of Nitrogen. [Federal Register Notice May 9, 2013]
|EPA held a public workshop to review initial draft materials to inform the development of the upcoming Integrated Science Assessment for Oxides of Nitrogen – Health Criteria. [Federal Register Notice May 10, 2013]
|EPA released the first external review draft for public review and comment. [Federal Register Notice November 22, 2013]
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- CASAC PEER REVIEW REPORT
- AGENCY RESPONSE TO CASAC REVIEW OF THE EPA’S INTEGRATED SCIENCE ASSESSMENT FOR OXIDES OF NITROGEN – HEALTH CRITERIA (FIRST EXTERNAL REVIEW DRAFT – NOVEMBER 2013)
- Integrated Science Assessment (ISA) for Oxides of Nitrogen – Health Criteria (Final Report, Jul 2008)
- Draft Plan for Development of the Integrated Science Assessment for Nitrogen Oxides Health Criteria