IRIS Toxicological Review of Naphthalene (2004, External Review Draft, Update)
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EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of naphthalene that when finalized will appear on the Integrated Risk Information System (IRIS) database.
U.S. EPA. IRIS Toxicological Review of Naphthalene (2004, External Review Draft, Update). U.S. Environmental Protection Agency, Washington, DC, NCEA-S-1707, 2004.
Naphthalene (CAS no. 91-20-3) is a bicyclic aromatic hydrocarbon with the chemical formula C10H8 and a molecular weight of 128.16. Pure naphthalene is a white, water-insoluble solid at room temperature with a vapor pressure of 0.087 mmHg (U.S. EPA, 1987; ATSDR,1993). Naphthalene is produced by distillation and fractionation of either petroleum or coal tar. Naphthalene’s principal use is as an intermediate in the production of phthalic anhydride. Phthalic anhydride is important in the manufacture of phthalate plasticizers, resins, dyes as well as insect and animal repellents. Naphthalene is also used in the manufacture of synthetic leather tanning agents and the insecticide carbaryl. Naphthalene has been used as a moth repellent and as a deodorizer for diaper pails and toilets (ATSDR, 1993; U.S. EPA, 1980, 1987).
This draft has been archived.
EPA is hereby providing for public information a draft Toxicological Review, draft IRIS Summary, and charge to external peer reviewers for EPA's health assessment of naphthalene. These documents are provided for public viewing during an external scientific peer review period. Sections of the documents pertaining to the inhalation carcinogenicity of naphthalene are the subject of the external review. While EPA is not soliciting public comments by this action, any scientific views received on the content of the Toxicological Review or IRIS Summary prior to August 13, 2004 will be considered in subsequent drafts.
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.