CASRN 108-88-3


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The U.S. EPA has conducted a second external peer review of the scientific basis supporting the health hazard and dose-response assessment for toluene that will appear on the Agency's online data base, the Integrated Risk Information System (IRIS). The draft Toxicological Review for Toluene and the draft IRIS Summary have undergone internal Agency review and previous external peer review (August 2002). As a result of the peer review, significant changes were made to the documents warranting further peer review. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization.


U.S. EPA. IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR TOLUENE (SECOND EXTERNAL REVIEW DRAFT). U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Washington Office, Washington, DC, NCEA-S-1264, 2003.


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Date Description
Aug 2002EPA released the first external review draft.
Jan 2004EPA released the second external review draft.
Sep 2005EPA released the final IRIS Toxicological Review and Summary Documents for Toluene.

Additional Information

EPA provided for public information a draft Toxicological Review, draft IRIS Summary, and the charge to external peer reviewers for EPA's health assessment of toluene. These documents are provided for public viewing prior to an external scientific peer review. While EPA is no longer soliciting public comments by this action, any scientific views received on the content of the Toxicological Review or IRIS Summary prior to February 19, 2004 were considered in subsequent drafts.

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This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

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