IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane (External Review Draft)
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EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of 1,1,2,2-tetrachloroethane that will appear on the Integrated Risk Information System (IRIS) database.
U.S. EPA. IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/001, 2009.
The draft Toxicological Review of 1,1,2,2-tetrachloroethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to subchronic and chronic exposure to 1,1,2,2-tetrachloroethane. 1,1,2,2 Tetrachloroethane (1,1,2,2TCE; CASRN 79-34-5) is a synthetic halogenated hydrocarbon that is a colorless, nonflammable liquid at room temperature. The major use for 1,1,2,2 tetrachloroethane was in the production of trichloroethylene, tetrachloroethylene, and 1,2-dichloroethylene. This assessment contains the derivation of both a subchronic and chronic reference dose and an oral cancer slope factor. EPA is also putting forth for external review the statement that the human carcinogenic potential of 1,1,2,2-tetrachloroethane is “likely to be carcinogenic to humans”.
|Mar 1987||An assessment for 1,1,2,2-tetrachloroethane is currently available on IRIS and contains a carcinogenicity assessment last revised in 1994.|
|2003||1,1,2,2-tetrachloroethane was nominated for reassessment by the Office of Air and Radiation/OAQPS and Region 4.|
|Sep 2009||EPA releases an external review draft of the assessment for public review and comment.|
|Dec 2009||EPA announces an external peer review workshop to be held on January 27, 2010 in a December 17, 2009 Federal Register Notice.|
|Feb 2010||EPA releases the comments from the public comment period and external review workshop.|
Following External Peer Review, the final assessment is scheduled to be posted to the IRIS database.
Comments on the assessment were submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the key word EPA- HQ-ORD-2009-0115 (for the docket ID).