US EPA

The U.S. EPA has conducted an external peer review of the scientific basis supporting the health hazard and dose response assessment for toluene that will appear on the Agency's online data base, the Integrated Risk Information System (IRIS). Peer review is meant to ensure that science is used credibly and appropriately in derivation of these dose-response assessments. The draft Toxicological Review for Toluene and draft IRIS Summary have undergone internal Agency review.

U.S. EPA. IRIS Toxicological Review and Summary Documents For Toluene (External Review Draft). U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Washington Office, Washington, DC, NCEA-S-1264, 2002.

Date	Description
01-Aug 2002	EPA released the first external review draft.
02-Jan 2004	EPA released the second external review draft.
03-Sep 2005	EPA released the final IRIS Toxicological Review and Summary Documents for Toluene.

EPA provided for public information a draft Toxicological Review, draft IRIS Summary, and the charge to external peer reviewers for EPA's health assessment of toluene. These documents are provided for public viewing prior to an external scientific peer review. While EPA is no longer soliciting public comments by this action, any scientific views received on the content of the Toxicological Review or IRIS Summary prior to September 27, 2002 were considered in subsequent drafts.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

• Instructions to Peer Reviewers for Reviewing IRIS Summaries and Supporting Documentation for Toluene (CAS No. 108-88-3) (PDF)  (2 pp, 17 KB, about PDF)
• Toxicological Review of Toluene [and IRIS Summary] (External Review Draft) (PDF)  (72 pp, 634 KB, about PDF)
• IRIS Summary - Toluene (External Review Draft) (PDF)  (21 pp, 239 KB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

• IRIS Toxicological Review and Summary Documents for Toluene (Second External Review Draft)