IRIS TOXICOLOGICAL REVIEW OF BENZENE (NONCANCER EFFECTS)
Notice - This site contains archived material(s).
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the NCEA Webmaster for assistance. Please use the contact form if you need additional assistance.
The Toxicological Review concludes that chronic benzene exposure may pose several types of noncancer human health hazards. Hematotoxicity, e.g., progressive deterioration of hematopoietic function, has been consistently reported to be the most sensitive indicator of noncancer toxicity in both experimental animal studies and occupationally exposed humans. The hazards can result from inhalation, oral or dermal exposure, though the exposure circumstances vary. The Toxicological Review includes estimates of chronic exposure levels for oral exposure (RfD) and inhalation exposure (RfC) that are thought to be without appreciable risk.
U.S. EPA. IRIS TOXICOLOGICAL REVIEW OF BENZENE (NONCANCER EFFECTS). U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Washington Office, Washington, DC, EPA/635/R-02/001F, 2002.
Louis J. D'Amico, Ph: 703-347-0344, Email: firstname.lastname@example.org
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.